https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Advances in non-coding RNA profiling for neurological diseases https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21388 Wed 11 Apr 2018 16:23:56 AEST ]]> Large scale gene expression meta-analysis reveals tissue-specific, sex-biased gene expression in humans https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28269 Wed 11 Apr 2018 15:33:28 AEST ]]> Estimating effect sizes and expected replication probabilities from GWAS summary statistics https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29038 Wed 11 Apr 2018 14:13:00 AEST ]]> Maternal smoking during pregnancy induces persistent epigenetic changes into adolescence, independent of postnatal smoke exposure and is associated with cardiometabolic risk https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45857 p level: 1.06 × 10-7), that were associated with maternal smoking during pregnancy, including associated genes AHRR (cancer development), FTO (obesity), CNTNAP2 (developmental processes), CYP1A1 (detoxification), MYO1G (cell signalling) and FRMD4A (nicotine dependence). A sensitivity analysis showed a dose dependent relationship between maternal smoking and offspring methylation. These results changed little following adjustment for paternal, passive or offspring smoking and there were no CpGs identified that associated with these variables. Two of the 23 identified CpGs (cg00253568 (FTO) and cg00213123 (CYP1A1)) were associated with either TG (males and females), diastolic blood pressure (females only) or HDL-C (males only), after Bonferroni correction. Discussion: This study demonstrates a critical timing of cigarette smoke exposure over the life-course for establishing persistent changes in DNA methylation into adolescence in a dose dependent manner. There were significant associations between offspring CpG methylation and adolescent cardiovascular risk factors, namely TG, HDL-C and diastolic blood pressure. Future studies on current smoking habits and DNA methylation should consider the importance of maternal smoking during pregnancy and explore how the persistent DNA methylation effects of in utero smoke exposure increase cardiometabolic risk.]]> Tue 08 Nov 2022 08:25:41 AEDT ]]> Integrating Sugar Metabolism With Transport: Elevation of Endogenous Cell Wall Invertase Activity Up-Regulates SlHT2 and SlSWEET12c Expression for Early Fruit Development in Tomato https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41582 Fri 05 Aug 2022 14:51:28 AEST ]]> Causal associations of urate with cardiovascular risk factors: two-sample Mendelian Randomization https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42787 ABCG2, SLC2A9, SLC17A1, SLC22A11, and SLC22A12 showed consistent causal effects of urate on HDL-C from all methods with 0.038 to 0.057 SD decrease in HDL-C per 1 mg/dl increase of urate, and no evidence of horizontal pleiotropy was detected. Conclusion: Our study suggests a significant and robust causal effect of genetically predicted urate on HDL-C. This finding may explain a small proportion (7%) of the association between increased urate and cardiovascular disease but points to urate being a novel cardiac risk factor.]]> Fri 02 Sep 2022 14:02:17 AEST ]]>